Gather Your Ingredients: Start by assembling all the ingredients, including ketchup, brown sugar, Worcestershire sauce, white vinegar, garlic powder, onion powder, salt, and pepper. Having everything ready will make the process smoother.
Combine Ingredients: Add the ketchup, brown sugar, Worcestershire sauce, and white vinegar in a medium-sized mixing bowl. Add a dash of garlic powder, onion powder, salt, and pepper to the mixture.
Whisk Until Smooth: Employ a wire whipping tool to blend the components thoroughly. Thoroughly mix the brown sugar until it dissolves to create a smooth and uniform sauce texture.
Taste and Adjust: Give the sauce a quick taste test. Consider increasing the amount of brown sugar slightly for a glaze with more sweetness. For extra tanginess, add a small splash of vinegar.
Apply to Meatloaf: Brush the sauce generously over your prepared meatloaf during the last 20-30 minutes of baking. This allows the glaze to caramelize perfectly without burning.
Optional Second Layer: For an extra-thick glaze, brush on a second layer of sauce about 10 minutes before removing the meatloaf from the oven.
Serve and Enjoy: Slice your meatloaf and serve it with additional sauce on the side for dipping. Combine with your preferred accompaniments to create a filling and delightful dinner.